Study 5

TITLE

[Clinical findings with a low-dosed antiandrogene (cyproteronacetate) and aethinyloestradiol women with virilising symptoms (author’s transl)]. Klinische Erfahrungen mit einem niedrig dosierten Antiandrogen (Cyproteronazetat) und Athinylostradiol bei Frauen mit Virilisierungserscheinungen

AUTHOR
Schmidt-Elmendorff H; Steyer M

SOURCE
Geburtshilfe Frauenheilkd 1977 Apr; 37 (4): 297-303

LANGUGE OF PUBLICATION
German (1350-)

ABSTRACT
The paper refers to 167 patients who were treated with 2 mg Cyproteronacetate and 50 mug Ethinyloestradiol because of acne, seborrhoea, hirsutism and androgenetic alopecia. The application was daily from the 5th to the 25th day of cycle over a period of 12 months. The success of treatment depended on the severity of virilisation: in cases of light acne only 77% of the patients showed improvement, while in cases of severe acne 91,4% showed improvement or healing of acne. The corresponding figures for seborrhoea were 55,7% and 89,4% respectively, and for hirsutism 37,4% and 60,9% respectively. Furthermore the success of treatment of the different virilising symptoms depended on the duration of therapy: while acne was already cured significantly after 6 months of treatment, seborrhoea and hirsutism show continuous improvement up to the 10th month thetherapy. Concerning side effects during therapy spottings and brake through bleedings were registered in 17,1 and 6% of cycles respectively. 16,2% of the patients noted breast tensions. Finally 68,7% of the patients suffered from nervousness, a very subjective symptom, which might be explained by the psychic lability accompanying virilising symptoms. The drop out rate was 7,8%, being not higher than with other oral contraceptives. (AUTHOR)

MJTR: Cyproterone TU. Ethinyl Estradiol TU. Virilism DT.

MNTR: Acne Vulgaris DT. Alopecia DT. Cyproterone AD. Cyproterone AE. Dermatitis, Seborrheic DT. English Abstract. Ethinyl Estradiol AD. Ethinyl Estradiol AE. Female. Hirsutism DT. Human. Menstruation Disorders DT. Time Factors.JOURNAL ARTICLE

GEOT: GERMANY, WEST

IDEN: ISSN: 0016-5751. JOURNAL-CODE: FK5. ENTRY-DATE: 770630. JOURNAL-SUBSET: M. IM-DATE: 7708.

ACCE: 77163234